Mitochondrial dysfunction and mitophagy: crucial players in burn trauma and wound healing

Abstract Burn injuries are a significant cause of death worldwide, leading to systemic inflammation, multiple organ failure and sepsis. The progression burn injury is explicitly correlated with mitochondrial homeostasis, which disrupted by the hyperinflammation induced injury, dysfunction cell death. Mitophagy plays crucial role in maintaining cellular homeostasis selectively removing damaged mitochondria. A growing body evidence from various disease models suggest that pharmacological interventions targeting mitophagy could be promising therapeutic strategy. Recent studies have shown wound healing injury. Furthermore, chemicals also been improve recovery, highlighting potential for novel strategies based on an in-depth exploration molecular mechanisms regulating its association skin healing.